The global trend towards decriminalisation and legalisation of cannabis use has brought increased attention to its association with psychosis (Murray & Hall, Reference Murray and Hall2020). One of these putative risk factors is cannabis. These three settings encompass a range of economic levels, resources, ethnic groups and cultures.Ī core aim of INTREPID II is to investigate the incidence and presentation of untreated psychotic disorders and associated risk factors in each setting. The programme is based in three catchment areas of Kancheepuram in Tamil Nadu, India, Ibadan in Oyo State Nigeria and seven municipalities in northern Trinidad, with populations at risk of approximately 500 000 in each setting. It has been designed to investigate variations in incidence, presentation, 2-year course and outcome, help-seeking and impact, as well as physical health with rates of untreated psychosis being used as a proxy for incidence (Morgan et al., Reference Morgan, Cohen, Esponda, Roberts, John, Pow and Williams2023). INTREPID II is a programme of research incorporating incidence, case–control and cohort studies of psychoses in the Global South (Roberts et al., Reference Roberts, Gureje, Thara, Hutchinson, Cohen, Weiss and Morgan2020). The Global South (Africa, Asia, Latin America and the Caribbean) contains 85% of the world's population yet most of our knowledge on psychotic disorders is based on research in North America, Western Europe and Australasia (Hamilton & Sumnall, Reference Hamilton and Sumnall2020 Hasan et al., Reference Hasan, von Keller, Friemel, Hall, Schneider, Koethe and Hoch2020 Marconi, Di Forti, Lewis, Murray, & Vassos, Reference Marconi, Di Forti, Lewis, Murray and Vassos2016).
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